职称：讲师

学历：博士

QQ：122636859

电子邮件：huangda@fzu.edu.cn

研究方向：生物医用材料

招生专业（方向）：生物医学工程（学硕）、生物技术与工程（专硕）

教育工作经历：

2017.08-至今 37000cm威尼斯 讲师

2020.02-2022.07 美国弗吉尼亚联邦大学/密苏里科技大学 博士后

2014.09-2017.07 中国科学院化学研究所 高分子化学与物理 博士

2011.09-2014.07 中国科学院化学研究所 材料工程 硕士

2007．09-2011.07 北京化工大学 高分子材料与工程 本科

教学简介：

本科生课程：《药物化学与药物分析》、《药剂学》、《生物高分子与胶体》、《生物医学纳米技术》

研究生课程:《纳米生物技术》、《药物递送系统》、《高分子与胶体化学》、《天然活性分子的功能与健康》。

科研简介：

主要从事生物医用材料的设计、制备及应用研究，包括（1）纳米药物递送系统的构建及其在炎症性疾病治疗方面的应用；（2）医用水凝胶的制备及其在抗感染伤口敷料、软骨修复等方面的应用；（3）可降解医用支架的制备及其在骨修复领域的应用；（4）检测疾病标志物的生物传感器的开发及应用。目前已在Biomaterials、Advanced Healthcare Materials、Carbohydrate Polymers、Biosensors & Bioelectronics、 Nanoscale等本领域知名国际期刊上发表SCI论文40余篇，其中第一作者和通讯作者论文20余篇，授权发明专利4项。

社会兼职：

（1）2022.06至今，担任Frontiers in Bioengineering and Biotechnology: Biomaterials期刊审稿编辑

（2）担任Carbohydrate Polymers、International Journal of Pharmaceutics、Materials Today Bio、International Journal of Biological Macromolecules、Food Chemistry、Biomaterials Science、Journal of Materials Chemistry B等国际学术期刊审稿人

（3）福建省福州市/莆田市科技特派员。

科研项目：

（1）福建省自然科学基金面上项目，兼具活性氧清除和多药递送功能的羟乙基淀粉-姜黄素微粒的制备及其用于炎症性肠病治疗的研究，2023-2026，主持

（2）福建省自然科学基金青年项目，酸响应多级释放纳米载体用于抗癌药物传输的研究，2019-2022，主持

（3）福建省教育厅中青年教师项目，姜黄素-茶多酚纳米药物的制备及应用，2018-2020，主持

（4）37000cm威尼斯科研启动经费，利用茶多酚制备疏水药物的新型纳米制剂的研究，2017-2020，主持

（5）技术开发项目，基于体表肿瘤、慢性创面与脂肪组织工程等整形外科亚专业的临床与基础研究，2023-2026，主持

（6）技术开发项目，纳米均孔膜的均相电化学发光传感器的技术开发，2023-2025，主持

（7）技术开发项目，氢气饱和生理盐水纳米铂的制备及应用，2020-2022，主持

（8）国家自然科学基金面上项目，高稳定性新型全无机无铅钙钛矿纳米材料的合成及应用，2023-2026，参与（第二）

（9）建省科技厅合作项目，基于金纳米团簇/二氧化钛光催化材料的制备及其创面抗菌作用的研究，2022-2025，参与（第二）

代表性论文：（*为通讯作者）

1. Da Huang, Jiahao Du, Fang Luo, Gang He, Minglang Zou, Yongming Wang, Zhenyu Lin,* Decheng Wu,* and Zuquan Weng.* Injectable hydrogels with integrated pH probes and ultrasound-responsive microcapsules as smart wound dressings for visual monitoring and on-demand treatment of chronic wounds. Advanced Healthcare Materials 2024, 2303379. IF=10

2. Da Huang, Minglang Zou, Chenlan Xu, Yongming Wang, Zhenjin Xu, Wancong Zhang,* Shijie Tang,* and Zuquan Weng.* Colon-targeted oral delivery of hydroxyethyl starch-curcumin microcapsules loaded with multiple drugs alleviate DSS-induced ulcerative colitis in mice. Macromolecular Bioscience 2024, 2300465. IF=4.6

3. Da Huang,* Qiang Tang, Minglang Zou, Yongming Wang, Fang Luo, Jinyi Mu, Yuanzi Wu, Zuquan Weng* and Zhenyu Lin. Anti-inflammatory unimolecular micelles of redox-responsive hyperbranched polycurcumin amphiphiles with enhanced anti-inflammatory efficacy in vitro and in vivo. Polymer Chemistry 2023, 14, 5208-5217. IF=5.364

4. Chenlan Xu, Shuting Chen, Cuiping Chen, Yangcan Ming, Jiahao Du, Jinyi Mu, Fang Luo, Da Huang,* Na Wang,* Zhenyu Lin and Zuquan Weng.* Colon-targeted oral nanoparticles based on ROS-scavenging hydroxyethyl starch-curcumin conjugates for efficient inflammatory bowel disease therapy. International Journal of Pharmaceutics 2022, 623, 121884. IF=6.51

5. Fang Luo, Yating Zhang, Yexin Zu, Shiqing Li, Yiting Chen, Zhonghui Chen, Da Huang,* Bin Qiu, Zhenyu Lin.* Quick preparation of water-soluble perovskite nanocomposite via cetyltrimethylammonium bromide and its application. Microchimica Acta 2022, 189, 68. IF=6.408

6. Da Huang, Kristoffer Valerie, Hu Yang.* Clickable biocompatible brush polymers as a versatile platform toward development of multifunctional drug delivery vehicles. Reactive and Functional Polymers 2022, 170, 105147. IF=4.966

7. Fang Luo, Shiqing Li, Limei Cui, Yexing Zu, Yiting Chen, Da Huang,* Zuquan Weng, Zhenyu Lin.* Biocompatible perovskite quantum dots with superior water resistance enable long-term monitoring of the H₂S level in vivo. Nanoscale 2021, 13, 14297-14303. IF=8.307

8. Shuting Chen, Jie Wu, Qiang Tang, Chenlan Xu, Yan Huang, Da Huang,* Fang Luo, Yuanzi Wu, Fen Yan, Zuquan Weng* and Shaoyun Wang. Nano-micelles based on hydroxyethyl starch-curcumin conjugates for improved stability, antioxidant and anticancer activity of curcumin. Carbohydrate Polymers 2020, 228, 115398. IF=10.723

9. Jiamin Chen, Yi Lu, Fen Yan, Yuanzi Wu, Da Huang* and Zuquan Weng*. A fluorescent biosensor based on catalytic activity of platinum nanoparticles for freshness evaluation of aquatic products. Food Chemistry 2020, 310, 125922. IF=9.231

10. Da Huang, Mi Sun, Yazhong Bu, Fang Luo, Cuiying Lin,* Zhenyu Lin, Zuquan Weng, Fei Yang* and Decheng Wu. Microcapsule-embedded hydrogel patches for ultrasound responsive and enhanced transdermal delivery of diclofenac sodium. Journal of Materials Chemistry B 2019, 7, 2330-2337. IF=7.571

11. Lixu Wang, Chaoqun Chen, Huawei Huang, Da Huang,* Fang Luo, Bin Qiu, Longhua Guo,* Zhenyu Lin and Huanghao Yang. Sensitive detection of telomerase activity in cancer cells using portable pH meter as readout. Biosensors & Bioelectronics 2018, 121, 153-158. IF=12.545

12. Da Huang, Yaping Zhuang, Fei Yang, Hong Shen, Xing Wang and Decheng Wu.* Acetal-linked PEGylated paclitaxel prodrugs forming free-paclitaxel-loaded pH-responsive micelles with high drug loading capacity and improved drug delivery. Materials Science & Engineering: C 2018, 82, 60-68. IF=8.457

13. Da Huang and Decheng Wu.* Biodegradable dendrimers for drug delivery. Materials Science & Engineering: C 2018, 90, 713-727. IF=8.457

14. Da Huang, Yaqiang Wang, Fei Yang, Hong Shen, Zuquan Weng and Decheng Wu.* Charge-reversible and pH-responsive biodegradable micelles and vesicles from linear-dendritic supramolecular amphiphiles for anticancer drug delivery. Polymer Chemistry 2017, 8, 6675-6687. IF=5.364

15. Da Huang, Fei Yang, Xing Wang, Hong Shen, Yezi You and Decheng Wu.* Facile synthesis and self-assembly behavior of pH-responsive degradable polyacetal dendrimers. Polymer Chemistry 2016, 7, 6154-6158. IF=5.364

16. Da Huang, Dawei Li, Tiantian Wang, Hong Shen, Pei Zhao, Baoxia Liu, Yezi You, Yuanzheng Ma,* Fei Yang,* Decheng Wu* and Shenguo Wang. Isoniazid conjugated poly(lactide-co-glycolide): long-term controlled drug release and tissue regeneration for bone tuberculosis therapy. Biomaterials 2015, 52, 417-425. IF=15.304

获奖情况

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