职务：助理研究员/硕士生导师

学历：博士

电子邮件： sailingzhang2016@hotmail.com

主要研究方向：合成生物学在肝癌生物治疗中的应用研究

教育工作经历：

1.2003/9–2007/7，厦门大学，生物科学类，学士

2.2007/9–2010/9，厦门大学，生物化学与分子生物学，硕士

3. 2010/11–2011/6，福建省疾病预防控制中心，医学实验动物科，技师

4.2011/9–2016/5，厦门大学，化学生物学，博士

5.2016/5–至今，福建医科大学孟超肝胆医院，助理研究员

6.2021/8–至今，37000cm威尼斯孟超医学与交叉科学中心，硕士生导师

科研简介：以肝癌生物治疗为研究目标，利用分子生物学技术从事光遗传学通路搭建以及溶瘤病毒基因工程改造。已在ACS Synthetic Biology、Small、Journal of Cell Science、Frontiers in Aging Neuroscience等国际刊物发表多篇SCI论文。参与国家自然科学基金2项，主持省部级项目3项，多项市局级项目。2022年入选福州市高层次人才（D类）。

科研项目：

1. 以肝细胞癌新生抗原为治疗靶点的腺病毒疫苗的开发与应用, 福建省自然科学基金（面上）项目，2021/11-2024/11，主持。

2. 光遗传学基因表达调控系统在双特异性抗体癌症治疗中的应用研究，福建省科技创新联合资金项目，2019/09-2022/09，主持。

3. 基于STIM1-Orai1相互作用新型光控分子开关的构建与应用，福建省自然科学基金（面上）项目，2018/04-2021/04，主持。

4. 多功能仿生纳米载体构建及其协同增强肝癌免疫检查点阻断治疗研究，国家自然科学基金（面上）项目，2023/01-2026/12，参与。

5. 肿瘤微环境H2O2触发的信号循环放大程序化控释纳米体系用于肿瘤协同治疗的研究，国家自然科学基金（面上）项目，2019/01-2022/12，参与。

已发表论文：

(1) Zhang Cuilin(#); Shi Yingjun(#); Wu Lingjie; Wang Chenyi; Liao Naishun; Wang Fei; Zhao Bixing; Wang Yingchao; Liu Xiaolong(*); Far-Red Light Triggered Production of Bispecific T Cell Engagers (BiTEs) from Engineered Cells for Antitumor Application, ACS Synthetic Biology, 2022, 11(2): 888-899

(2) Zhang Cuilin(#); Zhuang Qiuyu(#); Liu Jingfeng(*); Liu Xiaolong(*); Synthetic Biology in Chimeric Antigen Receptor T (CAR T) Cell Engineering, ACS Synthetic Biology, 2022, 11(1): 1-15

(3) Zhang Da(#); Zhang Cuilin(#); Lan Shanyou; Huang Yanbing; Liu Jingfeng; Li Juan(*); Liu Xiaolong(*); Yang Huanghao(*); Near-Infrared Light Activated Thermosensitive Ion Channel to Remotely Control Transgene System for Thrombolysis Therapy, Small, 2019, 15(27)

(4) Zhang Cuilin(#); Tan Zhenqiu(#); Xie Yongzhuang(#); Zhao Yingjun; Huang Timothy Y.; Lu Zhaoping; Luo Hong; Can Dan; Xu Huaxi; Zhang Yun-wu(*); Zhang Xian(*); Appoptosin Mediates Lesions Induced by Oxidative Stress Through the JNK-FoxO1 Pathway, Frontiers in Aging Neuroscience, 2019, 11:243

(5) Zhang Cuilin; Shi Zhun; Zhang Lingzhi; Zhou Zehua; Zheng Xiaoyuan; Liu Guiying; Bu Guojun; Paul E. Fraser; Xu Huaxi; Zhang Yun-wu(*); Appoptosin Interacts with Mitochondrial Outermembrane Fusion Proteins and Regulates Mitochondrial Morphology, Journal of Cell Science, 2016, 129(5): 994-1002

(6) Ming Wu(#); Hao Li(#); Cao Zhang(#); Yingchao Wang(#); Cuilin Zhang; Yuting Zhang; Aoxue Zhong; Da Zhang; Xiaolong Liu(*); Silk-Gel Powered Adenoviral Vector Enables Robust Genome Editing of PD-L1 to Augment Immunotherapy across Multiple Tumor Models, Adv Sci (Weinh), 2023 Apr; 10(12): e2206399

(7) Aixian Zheng(#); Yanlin Du(#); Yiru Wang(#); Youshi Zheng; Zhaoyu Ning; Ming Wu; Cuilin Zhang; Da Zhang;  Jingfeng Liu; Xiaolong Liu(*); CD16/PD-L1 bi-specific aptamer for cancer immunotherapy through recruiting NK cells and acting as immunocheckpoint blockade, Mol Ther Nucleic Acids, 2022 Jan 19;27:998-1009

(8) Youshi Zheng; Cuilin Zhang; Zisen Lai; Yongyi Zeng; Juan Li; Da Zhang(*); Xiaolong Liu(*); Redirecting natural killer cells to potentiate adoptive immunotherapy in solid tumors through stabilized Y-type bispecific aptamer, Nanoscale, 2021 Jul 7;13(25):11279-11288

(9) Shuangying Qiao; Fuli Xin; Ming Wu; Youshi Zheng; Bixing Zhao; Cuilin Zhang; Xiaolong Liu; Zuwu Wei(*); Jingfeng Liu(*); A remotely controlled NIR-II photothermal-sensitive transgene system for hepatocellular carcinoma synergistic therapy, J Mater Chem B, 2021 Jun 30;9(25):5083-5091

(10) Yanlin Du(#); Da Zhang(#); Yiru Wang; Ming Wu; Cuilin Zhang; Youshi Zheng; Aixian Zheng(*); Xiaolong Liu(*); A highly stable multifunctional aptamer for enhancing antitumor immunity against hepatocellular carcinoma by blocking dual immune checkpoints, Biomater Sci, 2021 Jun 4;9(11):4159-4168

(11) Peiwen Yu; Dongye Zheng; Cuilin Zhang; Ming Wu(*); Xiaolong Liu(*); Protocol to prepare functional cellular nanovesicles with PD1 and TRAIL to boost antitumor response, STAR Protoc, 2021 Feb 8;2(1):100324

(12) Bixing Zhao(#); Xiaoyuan Zheng(#); Xionghong Tan; Kun Ke; Fei Wang; Yingchao Wang; Xiaohua Xing; Cuilin Zhang; Ping Hu; Shubing Lan; Qin Li; Aimin Huang(*); Xiaolong Liu(*); Ku80 negatively regulates the expression of OCT4 via competitive binding to SALL4 and promoting lysosomal degradation of OCT4, Int J Biochem Cell Biol, 2020 Jan;118:105664

(13) Naishun Liao; Yingjun Shi; Cuilin Zhang; Youshi Zheng; Yingchao Wang; Bixing Zhao; Yongyi Zeng; Xiaolong Liu(*); Jingfeng Liu(*); Antioxidants inhibit cell senescence and preserve stemness of adipose tissue-derived stem cells by reducing ROS generation during long-term in vitro expansion, Stem Cell Res Ther , 2019 Oct 17;10(1):306

(14) Ming Li; Xiao-Mo Wu; Ju Gao; Fen Yang; Cuilin Zhang; Kun Ke; Ying-Chao Wang; You-Shi Zheng; Jian-Feng Yao; Ying-Ying Guan; Xuan Chen; Juan Chen; Xiao-Long Liu; Xiao-Yu Yang; Mutations in the P10 region of procaspase-8 lead to chemotherapy resistance in acute myeloid leukemia by impairing procaspase-8 dimerization, Cell Death Dis, 2018 May 1;9(5):516

(15) Bixing Zhao(#); Yingchao Wang(#); Xionghong Tan; Xiaoyuan Zheng; Fei Wang; Kun Ke; Cuilin Zhang; Naishun Liao; Yuan Dang; Yingjun Shi; Youshi Zheng; Yunzhen Gao; Qin Li; Xiaolong Liu(*); Jingfeng Liu(*),An Optogenetic Controllable T Cell System for Hepatocellular Carcinoma Immunotherapy, Theranostics, 2019; 9(7): 1837–1850

(16) Yongzhuang Xie(#); Mengxi Niu(#); Chengxiang Ji; Timothy Y Huang; Cuilin Zhang; Ye Tian; Zhun Shi; Chen Wang; Yingjun Zhao; Hong Luo; Dan Can; Huaxi Xu; Yun-Wu Zhang(*); Xian Zhang(*); SNX8 Enhances Non-amyloidogenic APP Trafficking and Attenuates Aβ Accumulation and Memory Deficits in an AD Mouse, Frontiers in Cellular Neuroscience, 2019 Sep 6;13:410.

(17) Yunzhen Gao; Gaoxiong Wang; Cuilin Zhang; Minjie Lin; Xiaolong Liu; Yongyi Zeng Y(*); Jingfeng Liu J(*); Long non-coding RNA linc-cdh4-2 inhibits the migration and invasion of HCC cells by targeting R-cadherin pathway, Biochemical and Biophysical Research Communications, 2016, 480: 348-354.

(18) Kunmu Zheng; Jing Zhang; Cuilin Zhang; Yunwu Zhang(*); Xiaochun Chen(*); Curcumin inhibits appoptosin-induced apoptosis via upregulating heme oxygenase-1 expression in SH-SY5Y cells, Acta Pharmacologica Sinica, 2015, 36: 544-52.

(19) Shangtong Jiang(#); Yanfang Li(#); Cuilin Zhang; Yingjun Zhao; Guojun Bu; Huaxi Xu; Yunwu Zhang(*); M1 muscarinic acetylcholine receptor in Alzheimer’s disease, Neuroscience Bulletin, 2014, 30: 295-307

(20) Longxin Qiu; Jianhui Lin; Fangui Xu; Yuehong Gao; Cuilin Zhang; Ying Liu; Yu Luo; James Y. Yang*; Inhibition of aldose reductase activates hepatic peroxisome proliferator-activated receptor-α and ameliorates hepatosteatosis in diabetic db/db mice. Experimental Diabetes Research, 2012, 2012: 789730

(21) Longxin Qiu; Cuilin Zhang; Jun Zhang; Jiaxin Liang; Jun Liu; Cishu Ji; James Y. Yang*; Intraperitoneal co-administration of thymosinα-1 ameliorates streptozotocin-induced pancreatic lesions and diabetes in C57BL/6 mice. International Journal of Molecular Medicine, 2009, 23: 597-602.