职称：副研究员

学历：博士

电话：

电子邮件：ibptcl@fzu.edu.cn

研究方向：天然药物化学/食品化学/药理学/药剂学

教育工作经历：

2012/7至今          37000cm威尼斯 副研究员

2008/7-2012/6    37000cm威尼斯 助理研究员

2006/7-2008/6    中国海洋大学药物化学专业 博士学位

2005/9-2006/6    韩国釜山市釜庆大学化学系 联合培养

2003/9-2005/8    中国海洋大学药物化学专业 硕博连读

1999/9-2003/6    中国海洋大学药学专业 学士学位

教学简介：

生物医学工程硕士专业课 《波谱分析》

生物工程硕士专业课 《绿色生物制造》、《生物资源开发利用》

科研简介：

先后主持国家自然科学基金、福建省卫教联合攻关项目，福建省自然科学基金和福建省高校青年重点项目等多项课题。以第一作者或者通讯作者发表SCI收录论文20余篇。授权国家发明专利40余项。先后被评为2012年度37000cm威尼斯优秀科技工作者和2018年度37000cm威尼斯阳光奖教金。

社会兼职：中国化学会会员，多个SCI杂志审稿人

科研项目：

1. 福建省自然科学基金“新型海洋微生物来源逆转肿瘤耐药先导物的发现及相关机制研究” 负责人 9万元2017-2020 (项目编号：2017J01855)

2. 福建省高校青年自然基金重点项目“海洋微生物来源逆转肿瘤耐药先导物的发现及机制研究” 负责人 10万元 2017-2019 (项目编号：JZ160419)

3. 福建省卫教联合攻关项目“循环肿瘤细胞及肿瘤干细胞分子特性在肠癌中的应用研究” 负责人 15万元 2013-2016 (项目编号：WKJ-FJ-14)

4. 福建省肿瘤生物治疗重点实验室开放基金“海洋药物先导物抗癌机制研究” 负责人 5万元 2014-2016 (项目编号：2014-11-1)

5. 国家自然科学基金项目“福建沿海微生物中诱导肿瘤细胞凋亡先导物的发现、优化及其机理研究” 负责人 25万元 2012-2014 (项目编号：21102015)

6. 福建省自然科学基金“闽江口湿地微生物抗氧化活性成分结构及生物活性的研究” 负责人 5万元2009-2011 (项目编号：2009J05075)

7. 37000cm威尼斯人才基金“闽江流域微生物活性成分结构研究” 负责人 5万元2009-2012 (项目编号：022229)

8. 37000cm威尼斯科技发展基金“闽江口湿地微生物抗氧化活性成分结构及生物活性的研究” 负责人 1.5万元2010-2012 (项目编号：2009-XY-16)

9. 天津市生物医学材料重点实验室开放基金“闽江口湿地微生物抗氧化活性成分研究” 负责人 2.5万元2010-2013

代表性论文：

1. Li Chen, Miaomiao Cheng, Ya-Ping Li, Shao-Feng Lin, Qiu-Hong Zheng, Qin-Ying Liu,* 4,4'‑Bond secalonic acid D targets SP cells and inhibits metastasis in hepatocellular carcinoma, Mol. Med. Rep., 2020, 21: 2624-2632.

2. Li Chen, Siyuan Wang, Qinying Liu,* Zhihong Zhang, Shaofeng Lin,, Qiuhong Zheng, Miaomiao Cheng, Yuying Li, Cui Cheng*. Reduction sensitive nanocarriers mPEG-g-γ-PGA/SSBPEI@siRNA for effective targeted delivery of survivin siRNA against NSCLC. Colloid. Surface. B, 2020, 193: 111105.

3. Cui Cheng, Zhihong Zhang, Siyuan Wang, Li Chen*, Qinying Liu*. Reduction sensitive CC9-PEG-SSBPEI/miR-148b nanoparticles: synthesis, characterization, targeting delivery and application for anti-metastasis. Colloid. Surface. B,2019, 183: 110412.

4. Wu Jiu-Lin*, Guo Xiao-Ban, Hui Liu, Chen Li*. Isolation and comparative study on the characterization of guanidine hydrochloride soluble collagen and pepsin soluble collagen from the body of surf clam shell (Coelomactra antiquate). Foods, 2019, 8(1): 1-13

5. Li Chen, Zhi-Hao Lu, Qin-Ying Liu,* Qiu-Hong Zheng, Lin Du, Qi-Qing Zhang*. Secalonic Acids J–M, Four New Secondary Metabolites from the Marine-Derived Fungus Penicillium oxalicum. Heterocycles, 2019, 98(7): 955-965.

6. Li Chen, Ya-Ping Li, Xin-Xin Li, Zhi-Hao Lu, Qiu-Hong Zheng and Qin-Ying Liu*, Isolation of 4,4’-bond secalonic acid D from the marine-derived fungus Penicillium oxalicum with inhibitory property against hepatocellular carcinoma, The Journal of Antibiotics, 2019, 72: 34–44.

7. Li Chen, Xinxin Li, Miaomiao Cheng, Siyuan Wang, Qiuhong Zheng* and Qinying Liu*,iso-pencillixanthone A from a marine-derived fungus reverses multidrug resistance in cervical cancer cells through down-regulating P-gp and re-activating apoptosis, RSC Advances, 2018, 8: 41192–41206.

8. Li Chen, Yang-Yang Zhao, Rong-Feng Lan, Lin Du, Bing-Shuai Wang, Tong Zhou, Ya-Ping Li, Qi-Qing Zhang, Min-Gang Ying, Qiu-Hong Zheng*, Qin-Ying Liu*. Dicitrinone D, an antimitotic polyketide isolated from the marine-derived fungus Penicillium citrinum. Tetrahedron, 2017, 73(40): 5900-5911.

9. Li Chen, Yan-Xue Bi, Ya-Ping Li, Xin-Xin Li, Qin-Ying Liu, Min-Gang Ying, Qiu-Hong Zheng, Lin Du,* and Qi-Qing Zhang*, Secalonic Acids H and I, Two New Secondary Metabolites from the Marine-Derived Fungus Penicillium oxalicum, Heterocycles, 2017, 94(9): 1766-1774.

10. Qin-Ying Liu, Tong Zhou, Yang-Yang Zhao, Li Chen*, Mei-Wei Gong, Qi-Wen Xia, Min-Gang Ying, Qiu-Hong Zheng*, Qi-Qing Zhang*. Antitumor Effects and Related Mechanisms of Penicitrinine A, a Novel Alkaloid with a Unique Spiro Skeleton from the Marine Fungus Penicillium citrinum, Mar. Drugs, 2015, 13(8): 4733-4753. 

11. Li Chen,* Tong Zhou, Yang-Yang Zhao, Mei-Wei Gong, Qi-Wen Xia, Min-Gang Ying, Qiu-Hong Zheng, Qin-Ying Liu, and Qi-Qing Zhang*, Four New Penicitrinols and Two New Penicillenols from the Marine-Derived Fungus Penicillium citrinum, Heterocycles, 2015, 91(5): 1007-1016.

12. Xiao Hu, Qi-Wen Xia, Yang-Yang Zhao, Qiu-Hong Zheng, Qin-Ying Liu, Li Chen*, Qi-Qing Zhang*, Speradines F–H, Three New Oxindole Alkaloids from the Marine-derived Fungus Aspergillus Oryzae, Chem. Pharm. Bull., 2014, 62(9)：942–946.

13. Xiao Hu, Qi-Wen Xia, Yang-Yang Zhao, Qiu-Hong Zheng, Qin-Ying Liu, Li Chen*, Qi-Qing Zhang*, Speradines B–E, Four Novel Tetracyclic Oxindole Alkaloids from the Marine-Derived Fungus Aspergillus Oryzae, Heterocycles, 2014, 89(7): 1662-1669.

14. Li Chen, Mei-Wei Gong, Zhen-Fei Peng, Tong Zhou, Min-Gang Ying, Qiu-Hong Zheng*, Qin-Ying Liu*, Qi-Qing Zhang, The Marine Fungal Metabolite, Dicitrinone B, Induces A375 Cell Apoptosis through ROS-Related Caspase Pathway. Marine Drugs, 2014, 12(4): 1939–1958.

15. Xiao Hu, Mei-Wei Gong, Wei-Wei Zhang, Qiu-Hong Zheng, Qin-Ying Liu, Li Chen*, Qi-Qing Zhang*, Novel cytotoxic metabolites from the marine-derived fungus  Trichoderma citrinoviride. Heterocycles, 2014, 89(1): 189–196.

16. Li Chen*, Ping Zhong, Jian-Ru Pan, Kang-Jin Zhou, Kai Huang, Zhe-Xiang Fang, Jiu-Lin Wu, Qi-Qing Zhang*, Asperelines G and H, Two New Peptaibols from the Marine-Derived Fungus Trichoderma asperellum. Heterocycles, 2013, 87(3), 645-655.

17. Li Chen*, Wei-Wei Zhang, Qiu-Hong Zheng, Qin-Ying Liu, Ping Zhong, Xiao Hu, Zhe-Xiang Fang, Qi-Qing Zhang*, Aculeatusquinones A-D, Novel Metabolites from the Marine-Derived Fungus Aspergillus aculeatus. Heterocycles, 2013, 87(4), 861-868.

18. Li Chen*, Kai Huang, Ping Zhong, Xiao Hu, Zhe-Xiang Fang, Jiu-Lin Wu, Qi-qing Zhang*, Tumonoic Acids K and L, Novel metabolites From the Marine-Derived Fungus Penicillium citrinum. Heterocycles, 2012, 85(2), 413-419.

19. Li Chen*, Wei Liu, Kai Huang, Xiao Hu, Zhe-Xiang Fang, Jiu-Lin Wu, Qi-qing Zhang*, Penicitrinols F–I, New Citrinin Derivatives From the Marine-Derived Fungus Penicillium citrinum. Heterocycles, 2011, 83(8), 1853-1858. 

20. Li Chen, Wei Liu, Xiao Hu, Kai Huang, Jiu-Lin Wu, Qi-qing Zhang*. Citrinin derivatives from the marine-derived fungus Penicillium citrinum. Chem. Pharm. Bull., 2011, 59(4), 515-517.

21.  Li Chen, De-hai Li, Sheng-xin Cai, Feng-ping Wang, Xiang Xiao, Qian-qun Gu*. A new cytotoxic metabolite from a deep sea derived fungus, Phialocephala sp. Acta Pharmaceutica Sinica, 2010, 45, 1275−1278.

22. Li Chen, Yuchun Fang, Tianjiao Zhu, Qianqun Gu*, Weiming Zhu*. Gentisyl alcohol derivatives from the marine-derived fungus Penicillium terrestre. J.Nat.Prod., 2008, 71, 66-70.

23. Li Chen, Yuchun Fang,Xiaodong Luo,Hongping He,Tianjiao Zhu, Hongbing Liu, Qianqun Gu*,Weiming Zhu*. Sulfated alkenes from the echinus Temnopleurus hardwickii. J.Nat.Prod., 2006, 69, 1787-1789. 

获奖情况：

2012年度37000cm威尼斯优秀科技工作者

2018年度37000cm威尼斯阳光奖教金

其他：